Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest
Out-of-hospital sudden cardiac arrest is a major public health problem with an overall survival of less than 5%.Upon cardiac arrest, cessation of coronary blood flow rapidly leads to intense myocardial ischemia and activation of the sarcolemmal Na+-H+ exchanger isoform-1 (NHE-1).NHE-1 activation drives Na+ into cardiomyocytes in exchange for H+ wit